Acta Pharm. 55 (2005) 47-56

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Original research paper  
 

Benzimidazolyl quinolinyl mercaptotriazoles as potential antimicrobial and antiviral agents

VINOD KUMAR PANDEY,* MRIDULA UPADHYAY, MRINALINI UPADHYAY, VISHNU DEV GUPTA and MEENAL TANDON

vinodkumarpandey@rediffmail.com; upadhyaymridu@ rediffmail.com

Department of Chemistry, University of Lucknow, Lucknow-226007 (U.P.), India
Received July 15, 2003      Accepted December 13, 2004

Condensation of ethylaceto acetate (EAA) with resorcinol in concentrated H2SO4 afforded 7-hydroxy-4-methyl coumarin (1) which on reaction with thiosemicarbazide in anhydrous pyridine yielded 7-hydroxy-4-methyl-quinolinyl [1,5-c]-mercaptotriazole (2). Reaction of 2 with formaldehyde solution and amino acid in ethanol yielded 7-hydroxy-4-methyl-8-(N-methyl-aminoacid)-quinolinyl [1,5-c]-2"-mercaptotriazole (3). Interaction of 3 with o-phenylenediamine in pyridine yielded 7-hydroxy-4-methyl-8-(aminobenzimidazolyl)-quinolinyl [1,5-c]-2"-mercaptotriazole derivatives (4a-e). The latter compounds were evaluated for their antiviral and antimicrobial activities.


Keywords: minimum inhibitory concentration, minimum essential medium, foetal bovine serum, cytotoxicity, mercaptotriazoles

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